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Editor: Renee Preston
Profession: Attorney at Law

Category: Isotretinoin

Isotretinoin (eye soe tret' i noyn) is a retinoid prescribed as a last resort for severe nodular acne in patients who have not responded to other treatments, oral or topical. It is taken orally, two times a day. It sometimes takes 4 to 6 weeks of treatment before noticing results; however, improvement should occur within 15 to 20 weeks.

Brand namesfor isotretinoin include Accutane and Roaccutane by Roche, Accure by Alphapharm, Aknenrmin by Mylan, Amesteem by Mylan, Claravis by Barr, Ciscutan by Pelpharma, Isohexal by Hexal Australia, Isotroin by Cipla, Sotret by Ranbaxy, and Oratane by Douglas Pharmaceuticals. It is available in 5, 10, 20, 30 and 40 mg capsules.

Isotretinoin was originally released by Hoffmann-La Roche in 1982. Since that time, numerous side effects have been reported, including depression, suicide, hair loss, severe birth defects, decreased night vision, degenerative disc disease, cartilage degeneration, bone disease, rosacea, arthralgias, congenital heart defects, and ischemic colitis.

If you or someone you know has experienced a severe side effect or reaction to isotretinoin or one of its brand names, you may want to contact an attorney for a free evaluation.